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Metastatic Breast Tumour Regression Following Treatment by a Gene-Modified Vaccinia Virus Expressing MUC1 and IL-2

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Author(s): Scholl Susy | Squiban Patrick | Bizouarne Nadine | Baudin Martine | Acres Bruce | von Mensdorff-Pouilly Silvia | Shearer Moira | Beuzeboc Philippe | Van Belle S. | Uzielly B. | Pouillart Pierre | Taylor-Papadimitriou Joyce | Miles David

Journal: Journal of Biomedicine and Biotechnology
ISSN 1110-7243

Volume: 2003;
Issue: 3;
Start page: 194;
Date: 2003;
Original page

ABSTRACT
MUC1 is expressed by glandular epithelial cells. It is overexpressed in the majority of breast tumours, making it a potential target for immune therapy. The objectives of the present study were to evaluate the anti-tumour activity and tolerance of repeated administration of TG1031 (an attenuated recombinant vaccinia virus containing sequences coding for human MUC1 and the immune stimulatory cytokine IL-2) in patients with MUC1-positive metastatic breast cancer. This was an open-label, randomised study comparing two dose levels, 5×10E6 and 5×10E7 pfu , with 14 patients in each arm. The treatment was administered intramuscularly every 3 weeks for the first 4 doses and every 6 weeks thereafter, until progression. Two patients had a partial tumour regression ( >50% ), and 15 patients had stable disease as their best overall response until at least the 5th injection. Partial regression lasted for 11 months in one patient and for 12 months in the second patient who then underwent surgical resection of her hepatic metastases. The most frequent adverse events included inflammation at injection site: 7 patients, itching or pain at injection site: 5 patients, and moderate fever: 6 patients. One responding patient developed antinuclear, anti-DNA, and increased anti-TPO antibodies after the fifth injection, and which resolved at the end of treatment. The treatment regimes were well tolerated with a low toxicity profile. Although clinical efficacy remains limited, this study demonstrates the potential use of MUC1-based immune therapy in breast cancer.

Tango Jona
Tangokurs Rapperswil-Jona

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