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Method Development And Validation For The Estimation Of Chlorambucil In Bulk And Pharmaceutical Dosage Forms Using UV-VIS Spectrophotometric Method

Author(s): *Suddhasattya Dey1, Himansu Bhusan Samal2, P. Monica2, Sandeep Reddy2, G. Karthik2, Rohit Gujrati 2 and B. Geeta

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 3244;
Date: 2011;
Original page

Keywords: Chlorambucil | Anti-Cancer | lmax | ICH | UV-VIS spectroscopy.

The present study describes a simple, accurate, precise and cost effective UV-VIS Spectrophotometric method for the estimation of Chlorambucil, an anti-cancerdrug, in bulk and pharmaceutical dosage form. The solvent used was acetonitrile and the lmax or the absorption maxima of the drug was found to be 258nm. A linearresponse was observed in the range of 2-10μg/ml with a regression coefficient of 0.9994. The method was then validated for different parameters as per the ICH(International Conference for Harmonization) guidelines. This method can be used for the determination of Chlorambucil in quality control of formulationwithout interference of the excipients.
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