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Methylprednisolone as adjuvant in treatment of acute respiratory distress syndrome owing to leptospirosis-a pilot study

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Author(s): Ittyachen Abraham | Lakshmanakumar V | Eapen C | Joseph M

Journal: Indian Journal of Critical Care Medicine
ISSN 0972-5229

Volume: 9;
Issue: 3;
Start page: 133;
Date: 2005;
Original page

Keywords: ARDS | Leptospirosis | Methylprednisolone | Noninvasive ventilation

ABSTRACT
Background: Acute respiratory distress syndrome (ARDS) owing to leptospirosis is associated with a high mortality. This is in spite of mechanical ventilation in a critical care setting. ARDS by its very nature, associated with economic constraints in our patients has made treating these patients a challenge. Objective: To study if combination of methylprednisolone and noninvasive ventilation is life-saving in ARDS owing to leptospirosis. Design: Interventional pilot study. Setting: Medical intensive care unit of a rural medical college hospital. Participants: Eight patients diagnosed to have ARDS owing to leptospirosis. Main outcome indicator: Survival. Results: Seven out of eight patients who were treated with methylprednisolone and noninvasive ventilation recovered fully to resume normal life. Conclusion: Methylprednisolone with noninvasive ventilation is life-saving in ARDS owing to leptospirosis.

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