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The MHC class I of Grass Carp (Ctenopharyngodon idellus) With Different Way to Present Peptide

Author(s): Jia Zhen-Hu

Journal: Journal of Animal and Veterinary Advances
ISSN 1680-5593

Volume: 11;
Issue: 9;
Start page: 1455;
Date: 2012;
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Keywords: MHC I | tapasin | grass carp | peptide | assembly | China

Major Histocompatibility Complex class I (MHC class I) proteins are critical for immune defenses against viruses. Polygeny and polymorphism of alleles contribute to the breadth of the immune response. In previous study, researchers showed that a MHC class I gene termed Ctid-AB190929 was found from a grass carp. It was a expressed gene from cDNA library. Now, characterization of a genomic clone from the same grass carp constructed fosmid genome library allows us to further analysis the MHC class I region. This clone carried whole MHC class I and tapasin gene. This MHC class I termed Ctid-UBA0201 was the classical MHC class I by genomic analysis. But the amino acid sequences of Ctid-UBA0201 were differed from that of Ctid-AB190929. As lower vertebrates, appear to use a single expressed MHC class I locus to present a wide variety of peptide to antigen. The Ctid-UBA0201 could be the allelic gene of Ctid-AB190929. As the tapasin gene may be a unexpressed gene by genomic analysis, the Ctid-UBA0201 may present a wide variety of peptide without the tapasin gene to control the assembly. It may preserve genetic diversity which can be exchanged when the species face a new pathogen.
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