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Micro-RNA in development

Author(s): Thikekar V.P. | Sawant J.J. | More M.K. | Nair V.K. | Athalekar P. | Patil D. | Kulkarni S. | Gomase V.S.

Journal: International Journal of Drug Discovery
ISSN 0975-4423

Volume: 1;
Issue: 2;
Start page: 18;
Date: 2009;
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Keywords: Micro-RNA | synaptic fractions | precursors | down regulation | adipogenesis | stem cell

This article reviews the available literature on the regulation of miRNA processing that occurswithin normal cells and embryonic stem cells, during development or in diseases such as cancer. Also,explains miRNA biogenesis process for which regulation occurs. RNA editing of miRNA precursors,regulation by RNA binding proteins, alterations in the levels of key processing proteins, as well as a numberof unknown mechanisms contribute to the regulation of miRNA processing as well as miRNA expressionpattern during adipogenesis.

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