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Microbial antibiotics for the treatment of cancers#

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Author(s): Govind Pandey1* and Madhuri S.1

Journal: Drug Invention Today
ISSN 0975-7619

Volume: 1;
Issue: 1;
Start page: 7;
Date: 2009;
Original page

Keywords: Cancer | microbial antibiotics | treatment of cancer

ABSTRACT
In the present era, a very frightful disease termed as ‘Cancer’ (malignant tumour or neoplasm) represents the largest cause of mortality and claims over 6 million people throughout the world every year. It is difficult to cure cancer as it may be uncontrollable and incurable.Nevertheless, the present review article explore about some microbial antibiotics (chemotherapeutic agents) produced by different species of fungi for prevention and treatment of various cancers. The main antibiotics used as anticancer agents are actinomycin D (dactinomycin) isolated from Streptomyces spp.; bleomycin from S. verticillus; daunomycin from S. coeruleorubidus; doxorubicin, epirubicin and idarubicinfrom S. peuceticus; geldanamycin from S. hygroscopicus; and mitomycin C from S. caespitosus. Actinomycin D is active against choriocarcinoma, Kaposi’s sarcoma, Wilms’ tumour, rhabdomyosarcoma and testis tumour. Bleomycin is used in cancers of germ-cell, cervix, head and neck. Daunomycin is prescribed in acute myelogenous and acute lymphocytic leukemias (blood cancers). Doxorubicin is employed for the treatment of soft tissue, oesteogenic and other sarcomas; Hodgkins’s disease; non-Hodgkins’s lymphoma; acute leukemia; breast, genitourinary, thyroid, lung and stomach cancers; and neuroblastoma and other childhood sarcoma. Epirubicin is indicated in breast cancer, while geldanamycin inhibits the experimental cancer. Idarubicin is effective against breast cancer and leukemia. Mitomycin C is used to treat theancers of lung, stomach, colon, rectum and anus.
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