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MicroRNA Set : A Novel Way to Uncover the Potential Black Box of Chronic Heart Failure in MicroRNA Microarray Analysis

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Author(s): Guomin Shi | Qinghua Cui | Youyi Zhang

Journal: Journal of Computer Science & Systems Biology
ISSN 0974-7230

Volume: 02;
Issue: 04;
Start page: 240;
Date: 2009;
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Keywords: Microarray | MicroRNA | Gene set | Heart failure | Cardiovascular disease

ABSTRACT
As the prime criminal among all the cardio-vascular diseases, chronic heart failure (CHF) is still far from being fully understood after decades of study by researchers. The booming bioinformatics studies, especially the microRNA (miRNA) microarray analysis, have significantly accelerated the uncovering of underlying mechanisms of human diseases. However, these miRNA researches mainly focus on single miRNA, paying less attention to the group characteristics of miRNAs, which may ignore the group characteristics of miRNAs. Here we introduce a novel miRNA set concept incorporation with a group analysis method of CHF miRNA microarray expression. Our results show great accordance with previous studies, and also reveal potential characteristics of miRNAs in CHF. Furthermore, this novel miRNA set approach may give us new insights into other diseases studies as well.
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