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Microspheres in cancer therapy

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Author(s): Rajput M | Agrawal P

Journal: Indian Journal of Cancer
ISSN 0019-509X

Volume: 47;
Issue: 4;
Start page: 458;
Date: 2010;
Original page

Keywords: Cancer | microspheres | TheraSpheres | SIR-Spheres

ABSTRACT
Cancer microsphere technology is the latest trend in cancer therapy. It helps the pharmacist to formulate the product with maximum therapeutic value and minimum or negligible range side effects. Cancer is a disease in which the abnormal cells are quite similar to the normal cells, with just minute genetic or functional change. A major disadvantage of anticancer drugs is their lack of selectivity for tumor tissue alone, which causes severe side effects and results in low cure rates. Thus, it is very difficult to target abnormal cells by the conventional method of the drug delivery system. Microsphere technology is probably the only method that can be used for site-specific action, without causing significant side effects on normal cells. This review article describes various microspheres that have been prepared or formulated to exploit microsphere technology for targeted drug therapy in various cancers. We looked at the usefulness of microspheres as a tool for cancer therapy. The current review has been done using PubMed and Medline search with keywords.
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