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MICROWAVE ASSISTED SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF HALOLITORALIN A AND ITS N-ALKYLATED ANALOGS

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Author(s): Himaja M | Patidar N.K | Karigar A.A | Ramana M.V | D. Munirajasekhar

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 6;
Start page: 1837;
Date: 2011;
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Keywords: Halolitoralin A | synthesis | antibacterial | antifungal | microwave.

ABSTRACT
Total microwave-assisted synthesis of Halolitoralin A (a cyclic hexapeptide) isolated from the ferment broth of a marine sediment-derived Halobacillus litoralis YS3106 and its two N-methyl and N-ethyl analogs were described and characterized by spectral data. The synthesized compounds were screened for antibacterial activity against gram-positive (Bacillus subtilis and Staphylococcus aureus), gram-negative (Escherichia coli and Pseudomonas aeruginosa) and antifungal activity against Candida albicans (Diamorphic fungi).
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