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Mirabegron for Overactive Bladder: A Novel, First-in-Class β3- Agonist Therapy

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Author(s): Mohammed Imran | Abul Kalam Najmi | Shams Tabrez

Journal: Urology Journal
ISSN 1735-1308

Volume: 10;
Issue: 3;
Start page: 935;
Date: 2013;
Original page

Keywords: mirabegron | β3 receptor agonist | urinary bladder | overactive | drug therapy

ABSTRACT
Purpose: To discuss the pharmacotherapeutic aspects of Mirabegron which is a first-inclassnovel β3 receptor agonist drug recently approved by the food and drug administration(FDA) for the treatment of overactive bladder (OAB).Materials and Methods: We conducted a computerized search of the MEDLINE/PUBMEDdatabases with the word Mirabegron, β3 receptor agonist and overactive bladder.Results: Effect of Mirabegron on β3 adrenergic receptor purportedly releases nitric oxide(NO) by an increase in intracellular Ca2+ through accumulation of cyclic adenosinemonophosphate (cAMP). Along with NO which relaxes the detrusor muscle, it alsoreleases an urothelial-derived inhibiting factor (UDIF) that inhibits contractions. It increasesthe bladder capacity by causing bladder relaxation during the storage phase.Conclusion: Mirabegron appears to be a promising treatment in OAB patients by shiftingits management from reducing detrusor over-activity to inducing relaxation. Also itlacks the troublesome side effects associated with the standard antimuscarinic management.
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