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Mitochondria-targeted antioxidant effects of S(-) and R(+) pramipexole

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Author(s): Ferrari-Toninelli Giulia | Maccarinelli Giuseppina | Uberti Daniela | Buerger Erich | Memo Maurizio

Journal: BMC Pharmacology
ISSN 1471-2210

Volume: 10;
Issue: 1;
Start page: 2;
Date: 2010;
Original page

ABSTRACT
Abstract Background Pramipexole exists as two isomers. The S(-) enantiomer is a potent D3/D2 receptor agonist and is extensively used in the management of PD. In contrast, the R(+) enantiomer is virtually devoid of any of the DA agonist effects. Very limited studies are available to characterize the pharmacological spectrum of the R(+) enantiomer of pramipexole. Results Using differentiated SH-SY5Y neuroblastoma cells as an experimental model, here we show that S(-) and R(+) pramipexole are endowed with equipotent efficacy in preventing cell death induced by H2O2 and inhibiting mitochondrial reactive oxygen species generation. Both pramipexole enantiomers prevented mitochondrial ROS generation with a potency about ten times higher then that elicited for neuroprotection. Conclusions These results support the concept of both S(-) and R(+) pramipexole enantiomers as mitochondria-targeted antioxidants and suggest that the antioxidant, neuroprotective activity of these drugs is independent of both the chiral 6-propylamino group in the pramipexole molecule and the DA receptor stimulation.
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