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Mitochondrial disfunction and apoptosis in leukemia cells

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Author(s): Annamaria PALLAG | Marcela BOTA | Aurel ARDELEAN | Ladislau RITLI | Ildiko SZABO | Mariana MURESAN

Journal: Analele Universitatii din Oradea, Fascicula Biologie
ISSN 1224-5119

Volume: TOM XV;
Start page: 68;
Date: 2008;
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Keywords: mitochondria | apoptosis | leukemia | cell metabolism | reactive oxigen species

ABSTRACT
Apoptosis or programmed cell death is a process which involves the intentional degradation of the cell from the inside, the participation of the mitochondria to propagate the apoptotic signal, the alteration of the phospholipid cell membrane composition, the perturbation and alteration of the cell metabolism.The antineoplastic drugs is inducing the apoptotic process in the sensitive cells.It have been studied acute lymphoblastic leukemia cells. Using Annexin V-PE Apoptosis Detection Kit and flow cytometer, the amount of cells undergoing apoptosis, in various stages of the antineoplasic treatment, was detected. At the same time, were monitored, the serum level of malondialdehyde. The results obtained confirm the alteration of the mitochondrial metabolism. We can observed the mitochondrial dysfunction role in cell apoptosis.
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