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Mitochondrial Haplogroups Associated with Japanese Centenarians, Alzheimer’s Patients, Parkinson’s Patients, Type 2 Diabetes Patients, Healthy Non-Obese Young Males, and Obese Young Males

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Author(s): Shigeru Takasak

Journal: Journal of Proteomics & Bioinformatics
ISSN 0974-276X

Volume: 4;
Issue: 5;
Start page: 106;
Date: 2011;
Original page

Keywords: mtSNPs | Haplogroup | Semi-supercentenarians | Centenarians | Alzheimer’s disease | Parkinson’s disease | Type 2 diabetes patients | Healthy non-obese young males | Obese young males | Radial basis function (RBF)

ABSTRACT
There are strong connections among mitochondria, aging, and a wide variety of diseases. In this paper, the relations between eight classes of Japanese people—96 centenarians, 112 semi-supercentenarians (over 105 years old but less than 116 years old), 96 Alzheimer’s disease (AD) patients, 96 Parkinson’s disease (PD) patients, 96 type 2 diabetes (T2D) patients, 96 T2D patients with angiopathy, 96 healthy non-obese young males and 96 healthy obese young males—and their mitochondrial single nucleotide polymorphism (mtSNP) frequencies at individual mtDNA positions of the entire mitochondrial genome were examined using the radial basis function (RBF) network and a modified RBF method. New findings of mitochondrial haplogroups were obtained for individual classes. The centenarians were found to be associated with the haplogroups D4b2a, B5b, and M7b2; the semi-supercentenarinas with B4c1a, F1, B4c1c1, B4c1b1, and M1; the AD patients with G2a and N9b1; the PD patients with N9a, G1a, B4e, and M7a1a; the T2D patients with D4b2b, M8a, and B5b; the T2D patients with angiopathy with N9a2, D4b1, and G2a; the healthy non-obese young males with D4g, N9a, D4b2b, and B4b/d/e; and the healthy obese young males with M7b2, D4b2b, B4c1, and M7a1a. These results are different from the previously reported haplogroup classifications. As the proposed analysis method can predict a person’s mtSNP constitution and probabilities of becoming a centenarian, AD patient, PD patient, or T2D patient, it may be useful in the initial diagnosis of various diseases or longevity.
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