Academic Journals Database
Disseminating quality controlled scientific knowledge

Moderate anxiety in pregnant women does not compromise gestational immune-endocrine status and outcome, but renders mothers to be susceptible for diseased states development: A preliminary report

ADD TO MY LIST
 
Author(s): Armando J. Martínez | Anahi Chavarría | Gabriel Gutiérrez-Ospina | Tania Romo-González | Beda Y. Retureta | Elly N. Sánchez-Rodríguez

Journal: Advances in Molecular Imaging
ISSN 2161-6728

Volume: 03;
Issue: 01;
Start page: 101;
Date: 2012;
Original page

Keywords: Gestation; Pregnancy; Anxiety | Progesterone; Estradiol; Pro-Inflammatory Cytokines; Anti-Inflammatory Cytokines; Immune Tolerance; Endocrine Deficiency

ABSTRACT
High anxiety levels during pregnancy commonly lead to clinical complications that affect the mother/child’s prenatal and perinatal health. Such complications are thought to result from combining deficiencies of the endocrine milieu and decreased immune tolerance that support pregnancy. It is yet unclear whether pregnant women subjected to moderate anxiety develop a similar state of endocrine deficits and compromised immune tolerance. Here, we evaluated this issue by monitoring endocrine and immune parameters during pregnancy in a sample of women suffering of moderate anxiety. The health of mothers and children, as well as the outcome of the pregnancies were also revised and recorded. Moderately anxious pregnant women present increments of state anxiety, serum cortisol and progesterone, but not of estradiol, as pregnancy progressed. No variations of leukocyte anti- and pro-inflammatory cytokine mRNA expression were found along pregnancy. However, these pregnant women did show an increased frequency of gestational and perinatal complications, conditions that had no major consequences for their health and that of their children at birth. Hence, moderate anxiety renders the mother to be susceptible to develop diseased states during or by the end of pregnancy, while keeping the endocrine milieu and immune tolerance reasonably in place.
Save time & money - Smart Internet Solutions     

Tango Jona
Tangokurs Rapperswil-Jona