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Modification of the Brief Smell Identification Test by Introduction of a Placebo

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Author(s): Grete Kjelvik | Ole Bosnes | Ragnhild Omli | Liv Heidi Skotnes | Asta K. Håberg | Linda R. White

Journal: Neuroscience & Medicine
ISSN 2158-2912

Volume: 03;
Issue: 02;
Start page: 125;
Date: 2012;
Original page

Keywords: B-SIT | Odor Identification | Scratch and Sniff Tests | Norwegian Population | Olfactory Testing | Neurodegenerative Diseases

ABSTRACT
Objective: To introduce the concept that there might be “nothing to smell” to the Brief Smell Identification Test (B-SIT), with a view to masking olfactory deficits, particularly from healthy control participants in research studies. Methods: Seventy-one elderly individuals, healthy for their age, were recruited to the study. They were blindfolded and carried out a modified B-SIT where one item had been replaced with a placebo, and one odour alternative answer to three other items was replaced by the alternative “none/other” (actual odour unchanged). Results: There was no overall difference in the median or mean score achieved by the cohort compared to results obtained previously using the conventional B-SIT. The replacement of the item “turpentine” with a placebo resulted in an improved score for the item in a Norwegian setting. The overall scores were not improved. Conclusions: It is possible to introduce the concept that there may be “nothing to smell” to the B-SIT without compromising the test for healthy control individuals. This may be a more appropriate approach to olfactory testing of control individuals or patients with suspected early neurodegenerative diseases.
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