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Modulation by IL-10 of antigen-induced allergic responses in mice

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Author(s): Zuany-Amorim Claudia | Vargaftig B Boris | Pretolani Marina

Journal: Memórias do Instituto Oswaldo Cruz
ISSN 0074-0276

Volume: 92;
Issue: suppl.2;
Start page: 141;
Date: 1997;
Original page

Keywords: interleukin-10 | eosinophils | mast cells | TNF-alpha | interleukin-5

ABSTRACT
Over the last few years, we examined the anti-allergic properties of interleukin (IL)-10 in different models of inflammation in the mouse, as well as against IgE-dependent activation of mouse bone marrow-derived mast cells (BMMC). We showed that IL-10, concurrently administered with ovalbumin, inhibited inflammatory cell accumulation in the airways and in the peritoneal cavity of sensitized mice, as well as the accompanying cytokine release. IL-10 also blocked antigen-induced cytokine generation by IgE-stimulated BMMC. Together, these results identify a novel biological property of IL-10, as a cytokine with potent anti-allergic activities.
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