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Modulatory effect of Curcumin in Pentylenetetrazol induced Kindling in rats

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Author(s): Vandana Sharmaa, Bimla Nehrub, Debasish Hotac, Sanjeev Sharmad, Anjana Munshia,e*

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 2891;
Date: 2011;
Original page

Keywords: Epilepsy | Pentylenetetrazol | Curcumin | Piperine | Carbamazepine | Bioavilability | EEG | HPLC.

ABSTRACT
The present study was designed to investigate the antiseizure efficacy of curcumin against experimental convulsions and kindling induced by Pentylenetetrazol(PTZ). Repeated administration of PTZ in subconvulsive doses (40mg/kg i.p) resulted in marked increase in the epileptiform discharges as recorded by electroencephalograph(EEG) in rats. Treatment with curcumin modulated the seizure activity and EEG wave pattern. To compare the anticonvulsant efficacy of curcumin,carbamazepine (CBZ), an effective anticonvulsant was used. Single dose bioavailability was studied using high performance liquid chromatography (HPLC)technique in treated animals and compared. Curcumin was administered along with piperine to enhance the bioavailability of the former. There was no significantalteration in absorption of carbamazepine when given along with curcumin. The treatment with antiepileptic drug CBZ showed a marked reduction in seizureactivity, amplitude and frequency of EEG waves in kindled rats. However, the conjunctive treatment of curcumin and carbamazepine in epileptic rats was moresignificant in reducing epileptic activity as compared to curcumin and carbamazepine treated groups separately. The present study clearly indicates that curcuminmodulates the epileptic seizures by antagonizing the effect of PTZ without interfering the bioavailability of other drugs administered.

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Tangokurs Rapperswil-Jona

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