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Molecular cross-talk between Helicobacter pylori and human gastric mucosa

Author(s): Vittorio Ricci, Marco Romano, Patrice Boquet

Journal: World Journal of Gastroenterology
ISSN 1007-9327

Volume: 17;
Issue: 11;
Start page: 1383;
Date: 2011;
Original page

Keywords: Helicobacter pylori | Gastric mucosa | Pathogen/host interaction | Gastric diseases | Bacterial virulence factors | CagA | VacA

Helicobacter pylori (H. pylori) has co-evolved with humans to be transmitted from person to person and to colonize the stomach persistently. A well-choreographed equilibrium between the bacterial effectors and host responses permits microbial persistence and health of the host, but confers a risk for serious diseases including gastric cancer. During its long coexistence with humans, H. pylori has developed complex strategies to limit the degree and extent of gastric mucosal damage and inflammation, as well as immune effector activity. The present editorial thus aims to introduce and comment on major advances in the rapidly developing area of H. pylori/human gastric mucosa interaction (and its pathological sequelae), which is the result of millennia of co-evolution of, and thus of reciprocal knowledge between, the pathogen and its human host.
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