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Molecular epidemiology of measles viruses in China, 1995–2003

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Author(s): Zhang Yan | Zhu Zhen | Rota Paul | Jiang Xiaohong | Hu Jiayu | Wang Jianguo | Tang Wei | Zhang Zhenying | Li Congyong | Wang Changyin | Wang Tongzhan | Zheng Lei | Tian Hong | Ling Hua | Zhao Chunfang | Ma Yan | Lin Chunyan | He Jilan | Tian Jiang | Ma Yan | Li Ping | Guan Ronghui | He Weikuan | Zhou Jianhui | Liu Guiyan | Zhang Hong | Yan Xinge | Yang Xuelei | Zhang Jinlin | Lu Yiyu | Zhou Shunde | Ba Zhuoma | Liu Wei | Yang Xiuhui | Ma Yujie | Liang Yong | Li Yeqiang | Ji Yixin | Featherstone David | Bellini William | Xu Songtao | Liang Guodong | Xu Wenbo

Journal: Virology Journal
ISSN 1743-422X

Volume: 4;
Issue: 1;
Start page: 14;
Date: 2007;
Original page

ABSTRACT
Abstract This report describes the genetic characterization of 297 wild-type measles viruses that were isolated in 24 provinces of China between 1995 and 2003. Phylogenetic analysis of the N gene sequences showed that all of the isolates belonged to genotype H1 except 3 isolates, which were genotype A. The nucleotide sequence and predicted amino acid homologies of the 294-genotype H1 strains were 94.7%–100% and 93.3%–100%, respectively. The genotype H1 isolates were divided into 2 clusters, which differed by approximately 2.9% at the nucleotide level. Viruses from both clusters were distributed throughout China with no apparent geographic restriction and multiple co-circulating lineages were present in many provinces. Even though other measles genotypes have been detected in countries that border China, this report shows that genotype H1 is widely distributed throughout the country and that China has a single, endemic genotype. This important baseline data will help to monitor the progress of measles control in China.

Tango Jona
Tangokurs Rapperswil-Jona

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