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Molecular markers (c-erbB-2, p53) in breast cancer.

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Author(s): Anil Kumar Agrawal | Michał Jeleń | Jerzy Rudnicki | Zygmunt Grzebieniak | Piotr Zukrowski | Ewa Nienartowicz

Journal: Folia Histochemica et Cytobiologica
ISSN 0239-8508

Volume: 46;
Issue: 4;
Start page: 449;
Date: 2009;
Original page

ABSTRACT
The aim of our study was to evaluate the correlation between clinical characteristics, histopatologic features and c-erbB-2 as well as p53 expression in cancer tissues. Breast cancer tissue was obtained from 184 female subjects with primary breast cancer. According to hormonal status patients were divided into two groups - 64 belonged to the premenopausal group and 120 to postmenopausal group. Each patient underwent mammectomy and axillary lymphadenectomy. c-erbB-2 protooncogene was detected in 54% cases, and was correlated with infiltrating type of cancer growth, as well as larger tumor size. The presence of p53 antioncogene was observed only in 33% of cases, mainly in infiltrating duct carcinomas. The incidence of c-erbB-2 and p53 positive cases was higher among subjects, whose ultrasound and mammography revealed malignancy. There was no correlation found between of c-erbB-2 expression and axillary lymph nodes involvement It seems probable, that c-erbB-2 and p53 status of cancer tissue may prove to be useful in assessment of the level of biological aggressiveness in breast carcinomas and hence can be used as a prognostic factor.
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