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Monitoring of mitotic index and frequency of micronuclei in evaluation of genotoxic potential of fumagillin (dicyclohexylamine) in vivo

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Author(s): Stevanović Jevrosima | Stanimirović Z. | Pejin Ivana I. | Lazarević M.

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 56;
Issue: 5-6;
Start page: 437;
Date: 2006;
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Keywords: fumagillin (dicyclohexylamine) | honey bee | nosemadisease | genotoxicity | mitotic index (MI) | micronuclei (MN)

ABSTRACT
Fumagillin (dicyclohexylamine) is a natural antibiotic, secreted by Aspergillus fumigatus. It is used in veterinary medicine against microsporidiosis in bees and fish, as well as in human medicine for the treatment of intestinal amebiasis, microsporidial keratoconjunctivitis and intestinal microsporidiosis due to Enterocytozoon bieneusi in patients with AIDS and other types of immunodeficiency. In this study, the genotoxicity of fumagillin was evaluated in mouse bone marrow cells using the mitotic index (MI) and micronucleus (MN) assay. Fumagillin was administered to BALB/c mice by gavage in doses of 25, 50, 75 mg/kg b.w., repeated for 7 days at 24h intervals, with water-sugar syrup as the negative control and cyclophosphamide as the positive control (40 mg/kg b.w) All experimental doses of fumagillin induced a significant decrease (p
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