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Monocyte Expression of Toll-like Receptor-4 in Patients with Stable Angina Undergoing Percutanoeus Coronary Intervention

Author(s): Bahador Bagheri | Bahram Sohrabi | Aliakbar Movassaghpur | Siminozar Mashayekhi | Afagh Garjani | Mehriar Shokri | Mohammad Noori | Alireza Garjani

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 9;
Issue: 3;
Start page: 149;
Date: 2012;
Original page

Keywords: Inflammation | Percutanoeus Coronary Intervention | Stable Angina | Toll Like Receptor-4

Background: Toll like receptors (TLRs) are well recognized players in inflammatory conditions. Among them TLR-4 is involved in chronic inflammatory processes such as formation of atherosclerotic plaques. Objective: The present study was aimed to exam-ine the effects of percutanoeus coronary intervention (PCI) as a revascularization method on monocyte expression of hTLR-4 and on the serum levels of two proinflam-matory cytokines (TNF-α and IL-1β). Methods: Blood samples were obtained from 41 patients with stable angina who were candidates for PCI. The samples were collected immediately before and 2h and 4h after PCI. The expression of hTLR-4 on CD14+ monocytes and the serum levels of TNF-α and IL-1β were measured using flowcytome-try and ELISA techniques, respectively. Results: By comparing the frequency of circu-lating hTLR-4+/CD14+ monocytes at different time points, it was observed that PCI pro-cedure up regulates the monocyte expression of hTLR-4 (p

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