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Morphometric analysis of the intimal reaction after stent implantation in iliac arteries submitted to angioplasty in pigs

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Author(s): Castro Júnior Cyro | Pereira Adamastor Humberto | Pasa Márcio Bastiani

Journal: Acta Cirurgica Brasileira
ISSN 0102-8650

Volume: 21;
Issue: 3;
Start page: 139;
Date: 2006;
Original page

Keywords: Angioplasty | Stents | Constriction/Pathologic | Vascular Diseases | Animal Experimentation

ABSTRACT
PURPOSE: To compare through digital morphometry, the intimal thickening of the common ilíac arteries (CIA) in pigs, submitted to angioplasty and angioplasty followed by stent implantation. METHODS: Angioplasty was performed in 10 pigs in both CIA, followed by a stent implantation in the left CIA. After four weeks, the aorto-iliac segment was dissected. Histologic slices where divided in three groups: left CIA in the area of the proximal (group 1) and distal (group 2) implantation site of the stent and the region of angioplasty in the right CIA (group 3). The histological slices were digitalized to be analyzed by morphometry with calculation of the luminal, intimal and media layers areas. Descriptive statistics analysis was performed through average and standard deviation of areas on each group, using ANOVA, with LSD Post-Hoc test (p

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