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Mortality and morbidity analysis in neonates supported by invasive mechanical ventilation

Author(s): Azer Kılıç Başkan | Özgül Salihoğlu | İlhan Tan | Bedir Akyol | Sami Hatipoğlu

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 3;
Issue: 4;
Start page: 483;
Date: 2012;
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Keywords: Neonate | invasive mechanical ventilation | mortality | morbidity

Objectives: To evaluate mortality, morbidity, and invasivemechanical ventilation complications in mechanicallyventilated neonates in a tertiary care hospital, Istanbul,Turkey.Materials and methods: The neonates followed on invasivemechanical ventilation from January 2008 to December2009 were included in the study. A chart is formed foreach patient to record patient delivery room and clinicaldata prospectively.Results: The study population consisted of 236 neonates.Eighty-five percent were born at ≤37 completed weeks ofgestation (n=201). Fifty-two percent (n=123) were males.The mean gestational age was 31.9±5 weeks. The meanbirthweight was 1870.8±921.8 g. Antenatal steroid ratewas 13.3% (n=20) in 150 cases born at ≤34 weeks of gestation.Respiratory distress syndrome (n=100, 42,3%),perinatal depression and asphyxia (n=51, 21,6%), andsepsis (n=47, 19.9%) were the commonest indications.Mechanical ventilation related complications (nosocomialinfection (n=57), pulmonary hemorrhage (n=30),pneumonia (n=10), pneumothorax (n=9), and atelectasis(n=4)) developed in 33.5% of neonates (n=79). Bronchopulmonarydysplasia was 9.3%, intracranial hemorrhage(≥grade 3) 8.47%, periventricular leukomalacia 5.93%,necrotizing enterocolitis (>stage 2) 0.42%, and retinopathyof prematurity (>stage 2) 2.96%. Mortality rate was30.17%. Neonates born at 1000 gram (p
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