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The mouse as a model for understanding chronic diseases of aging: the histopathologic basis of aging in inbred mice

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Author(s): John P. Sundberg | Annerose Berndt | Beth A. Sundberg | Kathleen A. Silva | Victoria Kennedy | Roderick Bronson | Rong Yuan | Beverly Paigen | David Harrison | Paul N. Schofield

Journal: Pathobiology of Aging & Age-related Diseases
ISSN 2001-0001

Volume: 1;
Start page: 1;
Date: 2011;
Original page

Keywords: pseudoxanthoma elasticum | rhabdomyosarcoma | MoDIS | The Jackson Aging Center | pulmonary adenoma

ABSTRACT
Inbred mice provide a unique tool to study aging populations because of the genetic homogeneity within an inbred strain, their short life span, and the tools for analysis which are available. A large-scale longitudinal and cross-sectional aging study was conducted on 30 inbred strains to determine, using histopathology, the type and diversity of diseases mice develop as they age. These data provide tools that when linked with modern in silico genetic mapping tools, can begin to unravel the complex genetics of many of the common chronic diseases associated with aging in humans and other mammals. In addition, novel disease models were discovered in some strains, such as rhabdomyosarcoma in old A/J mice, to diseases affecting many but not all strains including pseudoxanthoma elasticum, pulmonary adenoma, alopecia areata, and many others. This extensive data set is now available online and provides a useful tool to help better understand strain-specific background diseases that can complicate interpretation of genetically engineered mice and other manipulatable mouse studies that utilize these strains.
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