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MRI findings in Kallmann syndrome

Author(s): Madan R | Sawlani Vijay | Gupta Sushil | Phadke R

Journal: Neurology India
ISSN 0028-3886

Volume: 52;
Issue: 4;
Start page: 501;
Date: 2004;
Original page

Keywords: Kallmann syndrome | Hypogonadotrophic hypogonadism | Anosmia | Magnetic Resonance Imaging | Olfactory system

Kallmann syndrome (KS) is a neuronal migration disorder characterised by hypogonadotrophic hypogonadism and anosmia or hyposmia. Five patients with clinical findings suggestive of KS were evaluated with MRI. All patients had abnormalities of olfactory system. Olfactory bulbs were absent in all patients. Olfactory sulci were absent in 3 patients and hypoplastic in 2 patients. Anterior pituitary was hypoplastic in two patients. The MRI findings in KS are characteristic and MRI is a useful adjunct to the diagnosis of KS.

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