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MUCOADHESIVE MICROSPHERES

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Author(s): A. Senthil | V.B. Narayanaswamy | I .Ajit | Galge Deepak S | Bhosale Rahul S

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 1;
Start page: 55;
Date: 2011;
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Keywords: mucosa | mucoadhesion | muco adhesive polymer microspheres

ABSTRACT
Bioadhesion can be defined as the process by which a natural or synthetic polymer can adhere to a biological substrate. When the biological substrate is a mucosal layer then it is known as mucoadhesion. Mucoadhesion is a currently used in the design of drug delivery system. Mucoadhesive microspheres provide a prolonged residence time at the site of application or absorption and facilitate an intimate contact with the underlying absorption surface and improve or better to therapeutic performance of drug. Mucoadhesive polymer are used to improving drug delivery by promoting the residence time and contact time of the dosage form with the mucous membranes, it adhere the mucosal surface in the body and the drug absorption by mucosal cells may be enhanced or released at the site for an extended period of time and enhanced bio availability of the drug to high surface to volume ratio. In recent years such mucoadhesive microspheres have been developed for oral, buccal , nasal, ocular, rectal, vaginal routes for either systemic or local effects. The aim of this article is review the principles underlaying the mucoadhesive polymer, methods of preparation and evaluation of muco adhesive microspheres.
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