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Multiple drug resistance patterns of fecal isolates of enteric bacterial species in Tigray, Northern Ethiopia: A 10-year retrospective analysis

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Author(s): Lidya Aguma Gemechu1, Girma Belachew Gutema1*, Ephrem Tekle Lemango2, Ayalew Mekonnen Ayele3,

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3259;
Date: 2011;
Original page

Keywords: Multiple drug resistance | pattern | fecal isolates | enteric bacteria | Tigray region

ABSTRACT
There has been a growing concern about the problem of antibiotic resistance Worldwide. Despite the availability of antibiotics, emergingantimicrobial resistance has become an increasing problem. National surveillance for this antimicrobial resistance is a well established norm in most industrializedcountries, while this is either less common or totally inexistent in the least developed and developing economies including Ethiopia. Objectives: Identifying themost dominant enteric bacterial isolates and assess their multiple drug resistance patterns over one decade in Tigray, Northern Ethiopia. Method: an institutionbased retrospective cross sectional study was conducted at Mekelle Clinical Regional Microbiological Laboratory from February to May 2011 on a 10 year records(September 2000 to August 2009 ) in Tigray region, Northern Ethiopia. Results: the common bacteria isolated were gram negative. E.coli, 183(60.4 %),Salmonella spp, 34(11.22%), Shigella spp 17(5.61%), Enterobacter spp, 15(4.95%), Proteus spp, 13(4.29%) and vibreocholera 12(3.96%). Overall resistance rateto Ampicillin in 2000 was 93.70% and increased to 100.0% in 2009 and Norfloxacin resistance rate for 2004 was 53.33% which decreased to 18.18% in 2008.Conclusion; The study showed that there is an alarming increase in resistance to commonly prescribed drugs like Ampicillin, Cotrimoxazole, andChloramphenicol and Tetracycline in Tigray region as were found out by other studies elsewhere. Almost all enteric bacteria isolated were resistant to more thanfive drugs making Multiple Drug Resistance (MDR) a major challenge.
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