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MULTIPLE UNIT DOSAGE FORM - PELLET AND PELLETIZATION TECHNIQUES: AN OVERVIEW

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Author(s): Kumar Vikash | Mishra Santosh Kumar | Lather Amit | Vikas | Singh Ranjit

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 1;
Start page: 121;
Date: 2011;
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Keywords: Pellets | Spheronization | Cryopelletization | Extrusion.

ABSTRACT
Pellets have been used in the pharmaceutical industry for more than four decades, with the advent of controlled release technology, that the full impact of the inherent advantages of pellets over single unit dosage forms have been realized, not only has focused on refining and optimizing existing pelletization techniques, but also focused on the development of novel approaches and procedures for manufacturing of pellets. The present review outlines the manufacturing and evaluation of pellets. There are various types of pelletization techniques like spheronization and extrusion, pelletization by layering, pelletization by solution layering & direct pelletization. The techniques namely extrusion-spheronization, hot melt extrusion, freeze pelletization, cryopelletization have been discussed along with parameters affecting pelletization.
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