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Multipotent mesenchymal stromal cells (MSCs): An overview

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Author(s): Harshit R. Shah*, Pravir Kumar*,# Rashmi K. Ambasta *, $

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3556;
Date: 2011;
Original page

Keywords: Migrain | Antiserotonergic activity | Abrus precatorius | sumatriptan.

ABSTRACT
Adult stem cells such as mesenchymal stem cells alias multipotent mesenchymal stromal cells (MSCs) as suggested by International Society for Cellular Therapy(ISCT) is one of the most promising cells that can be used for therapeutic purposes. Present in different tissues such as bone marrow, adipose tissue, umbilical cord,umbilical cord blood, menstrual blood and many other sources makes it one of the most readily available, non controversial source for clinical purposes. Apart fromits direct role in homing and differentiating into a specific lineage under the influence of various chemokines and cytokines in vitro as well as in vivo, thispopulation of cells consistently secretes certain factors which enhances not only its own chance of engrafting but also increases the chances and efficiency of otherunmatched cells like hematopoietic stem cells, when co-transplanted, by chemically interacting with the host cells especially with those involved in maintaininghost defense system, thus making it suitable for allogeneic transplantation. But with the advent of induced pluripotent stem cells (IPSCs) in the recent years,research in the area of mesenchymal stem cell biology has been abated. Since a plethora of things about IPSCs remain unknown, one has to consider alternativeapproaches for the common goal. Hence it will be in the best interest of all to reckon the use of extremely potential MSCs. This review is mainly to throw lighton missing perspectives of MSCs in its efficacy in treating several physiological conditions such as Diabetes, Peripheral arterial disease, Alzheimer’s disease,Parkinson’s disease etc.
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