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Multivariate Survival Analysis of Patients with Stage I NSCLC

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Author(s): Jun PEI | Baohui HAN | Jie ZHANG | Aiqin GU

Journal: Chinese Journal of Lung Cancer
ISSN 1009-3419

Volume: 14;
Issue: 12;
Start page: 926;
Date: 2011;
Original page

Keywords: Lung neoplasms | Prognosis | Survival analysis

ABSTRACT
Background and objective The effectiveness of adjuvant chemotherapy in providing survival advantage for stage I non-small cell lung cancer (NSCLC) patients, especially those with stage Ib NSCLC, remains to be determined. The seventh edition of the Tumor Node Metastasis (TNM) Classification of Malignant Tumors is due to be published in 2009. The aim of the current study is to validate the value of this classification in Chinese early-stage NSCLC. The benefits of adjuvant chemotherapy to patients with early-stage NSCLC were also assessed. Methods The new staging project was validated in 433 patients who underwent complete surgical resection for early-stage NSCLC at the Single Institution of Shanghai Chest Hospital from June 1998 to June 2010. This new parameter was combined with other well-established prognostic factors, and multivariate survival analysis were performed. Variables in the analysis included age, gender, history of smoking, pathologic type, type of resection (pneumonectomy, lobectomy, bilobectomy, and sleeve resection), tumor size (largest tumor dimension), T-status, lymphovascular vessel invasion, and adjuvant chemotherapy. Results The three-year overall survival rates for females and males are 89.22% and 77.53%, respectively (P=0.001,8). Elder patients have worse prognoses: the survival rates for those aged ≥70 and
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