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Murine lines as efficient biomodels in genotoxicity assays

Author(s): Daniel Francisco Arencibia Arrebola | Luis Alfredo Rosario Fernández | Yolanda Emilia Suárez Fernández | Alexis Vidal Novoa

Journal: RETEL : Revista de Toxicología en Línea
ISSN 1668-091X

Volume: 35;
Start page: 43;
Date: 2011;
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Keywords: Comet assay | micronucleus | chromosomal aberrations | sperm | rats | mice

In this article we give to know the results of 5 years of studies of our work team when evaluating and to compare the efficiency as biomodels in genotoxicity assay of different strains of mice and rats in both sexes. In all the evaluated assays the line of Balb/c mice turned out to be the ideal biomodel, found lower spontaneous indexes and induced high indexes to the mutagen used. These results demonstrate that genetically line of Balb/c in both sexes is more stable than the others tested.
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