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Muscle Research and Gene Ontology: New standards for improved data integration

Author(s): Feltrin Erika | Campanaro Stefano | Diehl Alexander | Ehler Elisabeth | Faulkner Georgine | Fordham Jennifer | Gardin Chiara | Harris Midori | Hill David | Knoell Ralph | Laveder Paolo | Mittempergher Lorenza | Nori Alessandra | Reggiani Carlo | Sorrentino Vincenzo | Volpe Pompeo | Zara Ivano | Valle Giorgio | Deegan née Clark Jennifer

Journal: BMC Medical Genomics
ISSN 1755-8794

Volume: 2;
Issue: 1;
Start page: 6;
Date: 2009;
Original page

Abstract Background The Gene Ontology Project provides structured controlled vocabularies for molecular biology that can be used for the functional annotation of genes and gene products. In a collaboration between the Gene Ontology (GO) Consortium and the muscle biology community, we have made large-scale additions to the GO biological process and cellular component ontologies. The main focus of this ontology development work concerns skeletal muscle, with specific consideration given to the processes of muscle contraction, plasticity, development, and regeneration, and to the sarcomere and membrane-delimited compartments. Our aims were to update the existing structure to reflect current knowledge, and to resolve, in an accommodating manner, the ambiguity in the language used by the community. Results The updated muscle terminologies have been incorporated into the GO. There are now 159 new terms covering critical research areas, and 57 existing terms have been improved and reorganized to follow their usage in muscle literature. Conclusion The revised GO structure should improve the interpretation of data from high-throughput (e.g. microarray and proteomic) experiments in the area of muscle science and muscle disease. We actively encourage community feedback on, and gene product annotation with these new terms. Please visit the Muscle Community Annotation Wiki

Tango Rapperswil
Tango Rapperswil

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