Academic Journals Database
Disseminating quality controlled scientific knowledge

Nano-TiO2/PEEK bioactive composite as a bone substitute material: in vitro and in vivo studies

Author(s): Wu XM | Liu XC | Wei J | Ma J | Deng F | Wei SC

Journal: International Journal of Nanomedicine
ISSN 1176-9114

Volume: 2012;
Issue: default;
Start page: 1215;
Date: 2012;
Original page

Xiaomian Wu1, Xiaochen Liu2, Jie Wei3, Jian Ma4, Feng Deng1, Shicheng Wei11Research Center for Oral Diseases and Biomedical Science, College of Stomatology, Chongqing Medical University, Chongqing, 2Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 3Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 4Hospital of Stomatology, Tongji University, Shanghai, People’s Republic of ChinaBackground: Compared with titanium (Ti) and other metal implant materials, poly(ether-ether ketone) (PEEK) shows outstanding biomechanical properties. A number of studies have also reported attractive bioactivity for nano-TiO2 (n-TiO2).Methods: In this study, n-TiO2/PEEK nanocomposites were prepared, taking advantage of the unique properties of both PEEK polymer and n-TiO2. The in vitro and in vivo bioactivity of these nanocomposites was assessed against a PEEK polymer control. The effect of surface morphology or roughness on the bioactivity of the n-TiO2/PEEK nanocomposites was also studied. n-TiO2/PEEK was successfully fabricated and cut into disks for physical and chemical characterization and in vitro studies, and prepared as cylindrical implants for in vivo studies. Their presence on the surface and dispersion in the composites was observed and analyzed by scanning and transmission electron microscopy and X-ray photoelectron spectroscopy.Results: Bioactivity evaluation of the nanocomposites revealed that pseudopods of osteoblasts preferred to anchor at areas where n-TiO2 was present on the surface. In a cell attachment test, smooth PEEK showed the lowest optical density value (0.56 ± 0.07) while rough n-TiO2/PEEK exhibited the highest optical density value (1.21 ± 0.34, P < 0.05). In in vivo studies, the percent bone volume value of n-TiO2/PEEK was approximately twice as large as that of PEEK (P < 0.05). Vivid three-dimensional and histologic images of the newly generated bone on the implants further supported our test results.Conclusion: Our study demonstrates that n-TiO2 significantly improves the bioactivity of PEEK, especially if it has a rough composite surface. A n-TiO2/PEEK composite with a rough surface could be a novel alternative implant material for orthopedic and dental applications.Keywords: polyether-ether-ketone, bioactivity, TiO2, nanocomposite, polymer, implant

Tango Rapperswil
Tango Rapperswil

     Affiliate Program