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Author(s): Alsteens David | Dague Etienne | Verbelen Claire | Andre Guillaume | Francius Grégory | Dufrêne Yves

Journal: Nanoscale Research Letters
ISSN 1931-7573

Volume: 2;
Issue: 8;
Start page: 365;
Date: 2007;
Original page

Keywords: AFM | Cells | Imaging | Force spectroscopy | Molecular recognition | Single molecule | Ultrastructure

AbstractRecent advances in atomic force microscopy (AFM) are revolutionizing our views of microbial surfaces. While AFM imaging is very useful for visualizing the surface of hydrated cells and membranes on the nanoscale, force spectroscopy enables researchers to locally probe biomolecular forces and physical properties. These unique capabilities allow us to address a number of questions that were inaccessible before, such as how does the surface architecture of microbes change as they grow or interact with drugs, and what are the molecular forces driving their interaction with antibiotics and host cells? Here, we provide a flavor of recent achievements brought by AFM imaging and single molecule force spectroscopy in microbiology.

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