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Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation

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Author(s): Beck Ruy Carlos R. | Haas Sandra Elisa | Guterres Silvia Stanisçuaski | Ré Maria Inês | Benvenutti Edilson V. | Pohlmann Adriana Raffin

Journal: Química Nova
ISSN 0100-4042

Volume: 29;
Issue: 5;
Start page: 990;
Date: 2006;
Original page

Keywords: nanocoating | nanoparticle | microparticle

ABSTRACT
The influences of the spray-drying parameters and the type of nanoparticles (nanocapsules or nanospheres) on the characteristics of nanoparticle-coated diclofenac-loaded microparticles were investigated by using a factorial design 3². Gastrointestinal tolerance following oral administration in rats was evaluated. Formulations were selected considering the best yields, the best encapsulation efficiencies and the lowest water contents, presenting surfaces completely coated by nanostructures and a decrease in the surface areas in relation to the uncoated core. In vitro drug release demonstrated the influence of the nanoparticle-coating on the dissolution profiles of diclofenac. Nanocapsule-coated microparticles presented a protective effect on the gastrointestinal mucosa.

Tango Jona
Tangokurs Rapperswil-Jona

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