Author(s): Seema V Pattewar | Deepak N Patil | Bharti V Bakade
Journal: Journal of Drug Delivery and Therapeutics
ISSN 2250-1177
Volume: 2;
Issue: 3;
Date: 2012;
Original page
ABSTRACT
The enhancement of the oral bioavailability is currently one of the greatest challenges in the development of poorly water soluble drugs. The main objective of work to enhance solubility of Simvastatin (SIM) by use of natural polymer, chitosan (CHI) and Hydroxy propyl methyl cellulose E3LV (HPMCE3LV), synthetic polymer to produce cost effective formulation. Physical mixture, co-grinding method, spray drying method are compared .Co-grinding method applied for preparation of drug polymer complex and compared with the solubility and dissolution of marketed preparation.
Journal: Journal of Drug Delivery and Therapeutics
ISSN 2250-1177
Volume: 2;
Issue: 3;
Date: 2012;
Original page
ABSTRACT
The enhancement of the oral bioavailability is currently one of the greatest challenges in the development of poorly water soluble drugs. The main objective of work to enhance solubility of Simvastatin (SIM) by use of natural polymer, chitosan (CHI) and Hydroxy propyl methyl cellulose E3LV (HPMCE3LV), synthetic polymer to produce cost effective formulation. Physical mixture, co-grinding method, spray drying method are compared .Co-grinding method applied for preparation of drug polymer complex and compared with the solubility and dissolution of marketed preparation.