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Neonatal Giant Cell Hepatitis in an Infant with Cystic Fibrosis

Author(s): Gholamhossein Fallahi | Fatemeh Bazvand | Kambiz Eftekhari | Faezeh Ahmadi | Maedeh Ahmadi | Nima Rezaei

Journal: Iranian Journal of Pediatrics
ISSN 2008-2142

Volume: 19;
Issue: 2;
Start page: 193;
Date: 2009;
Original page

Keywords: Cystic Fibrosis | Cholestasis | Giant cell hepatitis | Neonatal hepatitis

Background: Cystic fibrosis is a hereditary disease of mucus and sweat glands characterized by respiratory infections and pancreatic insufficiency. Case presentation: We describe a girl infant with cholestasis as of the first clinical presentation at the age of 1 month. She developed severe anemia which required transfusion for several times. High level of direct bilirubin, low level of albumin and positive sweat tests were detected in laboratory tests. Histopathology report of liver biopsy indicated giant cell neonatal hepatitis. Conclusion: Although neonatal hepatitis is common cause of neonatal cholestasis, such condition is quite rare in cystic fibrosis, which easily could be misdiagnosed. Early diagnosis and appropriate treatment could prevent further complications of the disease.
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