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NEPHROPROTECTIVE ACTIVITY OF CYANOTIS FASCICULATA VAR., FASCICULATA AGAINST CISPLATIN INDUCED NEPHROTOXICITY

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Author(s): Murthy R.L.N | Nataraj H.N | Ramachandra Setty S

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 9;
Start page: 137;
Date: 2011;
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Keywords: CFEE | Cisplatin | Nephroprotection | BUN | Creatinine | Antioxidants | GSH | LPO.

ABSTRACT
Cisplatin is quite effective against various neoplastic diseases, but its potential nephrotoxicity leads to increased morbidity, complications and hospitalization costs. Prevention of nephrotoxicity may allow clinicians to administer higher doses for added therapeutic benefits. So, the present investigation was designed to evaluate the ability of the 70% hydro-alcoholic extract of Cyanotis fasciculata Var., fasciculata (CFEE) to combat Cisplatin induced nephrotoxicity. Where, CFEE demonstrated dose dependent decrement of elevated biochemical markers of nephrotoxicity along with significant restoration of protective-GSH levels and suppression of LPO levels in tissues. Further, the remarkable renal-cellular rejuvenation found in histopathological studies also enunciated the organ protective activity of CFEE. It was concluded that, in addition to polyphenolics, some of the phyto-fragments found during GC-MS analysis might also contributed to the protection offered by CFEE.
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