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Nephroprotective effect of Bauhinia variegata (linn.) whole stem extract against cisplatin-induced nephropathy in rats

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Author(s): Pani Saumya | Mishra Satyaranjan | Sahoo Sabuj | Panda Prasana

Journal: Indian Journal of Pharmacology
ISSN 0253-7613

Volume: 43;
Issue: 2;
Start page: 200;
Date: 2011;
Original page

Keywords: Cisplatin | nephrotoxicity | Kanchana

ABSTRACT
The nephroprotective activity of the ethanolic extract of Bauhinia variegata (Linn.) whole stem against cisplatin-induced nephropathy was investigated by an in vivo method in rats. Acute nephrotoxicity was induced by i.p. injection of cisplatin (7 mg/kg of body weight (b.w.)). Administration of ethanol extract at dose levels of 400 and 200 mg/kg (b.w.) to cisplatin-intoxicated rats for 14 days attenuated the biochemical and histological signs of nephrotoxicity of cisplatin in a dose-dependent fashion. Ethanol extract at 400 mg/kg decreased the serum level of creatinine (0.65 ± 0.09; P
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