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Nephroprotective effects of the aqueous root extract of Harungana madagascariensis (L.) In acute and repeated dose acetaminophen renal injured rats

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Author(s): A A Adeneye | J A Olagunju | A S Benebo | S O Elias | A O Adisa | B O Idowu | M O Oyedeji | E O Isioye | O B Braimoh | O O Oladejo | E O Alana

Journal: International Journal of Applied Research in Natural Products
ISSN 1940-6223

Volume: 1;
Issue: 1;
Start page: 6;
Date: 2008;
Original page

Keywords: Harungana madagascariensis (L.) | root aqueous extract | acetaminophen nephrotoxicity | renal function parameters | hematological profile | Wistar rats

ABSTRACT
Summary: In African traditional medicine, decoctions from different parts of Harungana madagascariensis (L.) are highly valued in the treatment of various human diseases including drug related renal disease. In the current study, effects of pretreatments with single daily oral 100 – 500 mg/kg/day of the root aqueous extract of Harungana madagascariensis were investigated in acute and repeated dose acetaminophen nephrotoxic rats for 24 hours and 14 days, respectively, using renal function parameters – serum urea (UR), uric acid (UA) and creatinine (CR). Effects of the extract pretreatments on the hematological and renal histological profile in acetaminophen nephrotoxic rats were also evaluated. Results showed that treatment with intraperitoneal acetaminophen for 24 hours and 14 days induced significant (p
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