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Nephrotoxicity Reduction by Fixed Dose Combination of Cephalosporins and Aminoglycosides in <I>Mus musculus</I> Mice

Author(s): V.K. Dwivedi | M. Chaudhary | A. Soni | S.M. Shrivastava

Journal: Asian Journal of Biochemistry
ISSN 1815-9923

Volume: 4;
Issue: 1;
Start page: 13;
Date: 2009;
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Keywords: nephrotoxicity | amikacin | antioxidant enzymes | antibiotics | Free radical

Mus musculus mice. Present findings showed that the activities of the antioxidant enzymes were significantly lowered along with increase in MDA (malonaldialdehyde) levels and extracellular antioxidants after single treatment of aminoglycosides (amikacin and tobramycin) as compared to control group. A significant improvement in antioxidant enzymes along with significant decrease in creatinine, total bilirubin, uric acid and malonaldialdehyde (MDA) levels were observed in fixed dose combination of cefepime plus amikacin as well as ceftazidime+tobramycin treated groups compared to amikacin and tobramycin alone treated group. These results indicate that a fixed dose combination of cephalosporins with aminoglycosides using chemical vector mediated technology acts as an antioxidant and prevents nephrotoxicity induced by aminoglycosides.]]>
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