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Neropsychiatric Aspects of Systemic Lupus Erythematosus in Children and Adolescents

Author(s): F. Neslihan İnal EMİROĞLU | Burcu SERİM

Journal: Nöropsikiyatri Arşivi
ISSN 1300-0667

Volume: 45;
Issue: 3;
Start page: 92;
Date: 2008;
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Keywords: Systemic lupus erythematosus | neuropsychiatric aspects | children and adolescents

Systemic lupus erythematosus (SLE) is an autoimmune multisystemic disease, and the central nervous system is one of the most common major systems to be involved. SLE patients having neurologic involvement were found to experience neuropsychiatric complications such as psychosis, seizures and various cognitive dysfunctions. Neuropsychiatric SLE (NP-SLE) can cause any form of affective illness. Psychiatric involvement can include mood lability, unusual elation, irritability and depression or psychosis. Diagnosis is difficult to make owing to the wide variety of neuropsychiatric manifestations of SLE. Corticosteroid usage can cause psychiatric events, and differentiating corticosteroid induced psychiatric episodes from neuropsychiatric manifestations of SLE may be difficult. Depression is especially frequent in patients with SLE, and differentiating depression caused by possible psychological effects of the chronic disease from organic depression is required concurrently. Cranial Magnetic Resonance Imaging (MRI) and Quantitative Electroencephalography (QEEG) can be useful for detecting specific involvement of the central nervous system. The pediatrician, specialists and the mental health team may work together to help the child and his or her family throughout the course of the illness. The primary physician should consult with a child psychiatrist when psychiatric symptoms are seen in terms of the differential diagnosis and treatment. (Archives of Neuropsychiatry 2008; 45: 92-6)

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