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Nerve conduction abnormalities in different stages of glucose intolerance

Author(s): Viswanathan Vijay | Seena Rajasekar | Nair Mamtha | Snehalatha Chamukuttan | Bhoopathy R | Ramachandran Ambady

Journal: Neurology India
ISSN 0028-3886

Volume: 52;
Issue: 4;
Start page: 466;
Date: 2004;
Original page

Keywords: Type 2 diabetes | Impaired glucose tolerance | Nerve conduction velocity

AIMS: To look for changes in nerve conduction velocity (NCV) in early stages of glucose intolerance, i.e. in impaired glucose tolerance (IGT) and in asymptomatic newly diagnosed Type 2 diabetic subjects (NDD). MATERIALS AND METHODS: A total of 225 subjects were categorized as: Group 1: Subjects with normal glucose tolerance (NGT), Group 2: IGT subjects and Group 3: NDD subjects. Motor (MCV) and Sensory nerve Conduction Velocity (SCV) measurements were done. RESULTS: The mean MCV was significantly lower in the NDD group (47 ± 5 m/s) when compared with the other two groups (IGT=50 ±4.5 m/s; NGT= 53 ± 4 m/s; P=0.0001). The IGT group of subjects also exhibited a significantly lower mean MCV when compared with the NGT subjects (P=0.0001). The mean SCV in the NDD group (42+10 m/s) was also significantly lower (P
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