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Neuroendocrine Differentiation is not a Malignant Index of Non-small Cell Lung Cancer

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Author(s): Liang DAI | Yu SUN | Xianghong LI | Keneng CHEN

Journal: Chinese Journal of Lung Cancer
ISSN 1009-3419

Volume: 14;
Issue: 8;
Start page: 646;
Date: 2011;
Original page

Keywords: Lung neoplasms | Neuroendocrine | Immunohistochemistry

ABSTRACT
Background and objective A debate has been ongoing whether non-small cell lung cancer(NSCLC) with neuroendocrine(NE) differentiation likely indicates malignant behavior, poor prognosis, and sensitivity to chemotherapy. In response to this issue, we retrospectively investigated NE differentiation in NSCLC patients who underwent anatomical pulmonary surgery. Methods A total of 274 patients who met the inclusion criteria through January 2000 to December 2008 were enrolled in this study because they had the detailed material and enough paraffin tumor samples for tissue microarray. The recommended antibody panel consisted of CgA, Syn, NCAM, Leu-7, PGP9.5, and MAP-2. We also counted Ki-67 in the tissues to present the nuclear proliferation index. The Kaplan–Meier estimator and the Cox proportional hazard model multivariate analysis were applied to observe the relationship between NE differentiation and postoperative survival of the patients. Results The Cox analysis of different NE score combinations on the prognosis of NSCLC after surgical treatment did not reach statistical significance (score 1, score 2, and score≥3 vs score 0, P=0.527; score 0 vs score ≥1, P=0.791; score
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