Academic Journals Database
Disseminating quality controlled scientific knowledge

Neuropeptide Y Increases Both Ingestion of a Self-Selection Macronutrient Diet and Fos Expression in the Medial Amygdala of Rats

ADD TO MY LIST
 
Author(s): Bruna Mombach Dietrich | Marli Sita Scalcon | Franklin Back | Bárbara B. Philippi Martins | Elisa Cristiana Winkelmann-Duarte | Alberto A. Rasia-Filho

Journal: Neuroscience & Medicine
ISSN 2158-2912

Volume: 04;
Issue: 03;
Start page: 123;
Date: 2013;
Original page

Keywords: Central Control of Appetite | Extended Amygdala | Feeding Behavior | Food Intake Behavior | Motivation

ABSTRACT
The rat posterodorsal medial amygdala (MePD) is responsive to the orexigenic neuropeptide Y (NPY) and is a putative candidate to participate in neural circuits that modulate feeding behavior. Here, we studied the effects of intracerebroventricular (icv) microinjection of NPY on the appetitive and food intake behaviors of rats under the paradigm of the self-selection macronutrient isolated diets [high-carbohydrate (high-CHO), high-protein and high-lipid food pellets]. At the same time, Fos expression was also evaluated in the MePD as a marker of local cellular activation. Adult male rats received icv microinjections of NPY (1mg and10mg/5mL, n = 10 and 8, respectively) whereas the control groups either received icv microinjection of artificial cerebrospinal fluid (5mL, n = 8) or underwent sham procedure (n = 8). The data were obtained after a fasting protocol. Feeding behavior was evaluated during a 2 h test period of free access to the selective diets. Rats in all groups preferred the high-CHO diet. Compared to controls, both doses of NPY increased the appetitive behaviors (searching for food and the frequency of attempts to eat any diet) and the percentage of animals eating high-CHO diet. However, only NPY at a dose of 1 μg led to a significant increase in food intake and showed a strong positive correlation with Fos expression in the MePD (p
Save time & money - Smart Internet Solutions     

Tango Rapperswil
Tango Rapperswil