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Neuropharmacological activity of the aqueous leaf extract of Croton zambesicus (euphorbiaceae) in some laboratory animals

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Author(s): Rashidat Oluwafunke Ayanniyi | Noel Nenman Wannang

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 7;
Issue: 2;
Start page: 161;
Date: 2008;
Original page

Keywords: Croton zambesicus | central nervous system | depressant | sedative | hypnotic

ABSTRACT
To determine the neuropharmacological activity of the leaf extract of Croton zambesicus in mice and chicks. The effect of aqueous leaf extract of Croton zambesicus on thiopental sodium – induced sleeping time in mice, on gross locomotor activity (GLA) in 2-day old chicks and effect of extract on apomorphine - induced stereotyped behavior in chicks were evaluated. The aqueous extract (1000 and 1500 mg/kg), administered per os (p.o), prolonged the thiopental sodium - induced sleeping time in mice. Extract (20-40 mg/kg i.p) produced a significant (P < 0.05) decrease in GLA in 2-day old chicks in a dose dependent manner. 40-60 mg/kg administered intraperitoneally (i.p) produced sedation and sleep with a significant (P < 0.05) decrease in onset and an increase in duration of sleep. The extract had an insignificant (P > 0.05) effect on apomorphine - induced stereotyped behavior in chicks. These results suggest that leaf extract of Croton zambesicus possesses CNS depressant, sedative, and hypnotic activity.
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