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Neuroprotetive Effect of Curcuma longa Alcoholic Extract on Peripheral Nerves Degeneration after Sciatic Nerve Compression in Rats

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Author(s): M. Tehranipour | R. Javaheri

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 9;
Issue: 8;
Start page: 889;
Date: 2009;
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Keywords: neuroprotective | Curcuma longa | compression

ABSTRACT
Wallerian degeneration in the CNS and PNS consists of degradation and phagocytosis of axons and their myelin sheath distal to the site of injury. The present study was undertaken to evaluate the possible antioxidant neuroprotective effect of Curcuma longa extract on neuronal death after sciatic nerve injury in rat. Treatment of Curcuma longa extract (100 mg kg-1, i.p.) at three different times (immediately, 3, 6 and 9 day after compression) significantly (p
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