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Neuropsychological Function in Patients with Major Depressive Disorder and Suicidal Attempt

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Author(s): Manoochehr Gharaipoor | Mohammad Kazem Atef-Vahid | Mehdi Nasr-Esfahani | Ali-asghar Asgharnejad Farid

Journal: Iranian Journal of Psychiatry and Clinical Psychology
ISSN 1735-4315

Volume: 12;
Issue: 4;
Start page: 346;
Date: 2007;
Original page

Keywords: Key words: depression | suicide | neuropsychological functions

ABSTRACT
 AbstractObjectives: Neuropsychological dysfunction in major depressive disorder may be associated with the suicide risk in these patients. In this study, neuropsychological functions in patients with major depre-ssion and at least one prior suicide attempt, in patients with major depre-ssion and no history of suicide attempt, and healthy controls were compared. Method: In this causal or ex post facto study, fifteen patients with non-psychotic major depressive disorder and at least one prior suicide attempt, fifteen patients with non-psychotic major depressive disorder who had no history of suicide attempts, and fifteen normal subjects were compared with one another based on their neuropsychological function. Subjects were selected upon their availability. Groups were matched for age, sex, and education. Using Wisconsin Card Sorting Test (WCST), Stroop Color-Word Test (SC-WT), Revised Wechsler Memory Scale (WMS-R), and Beck’s Depression Inventory (BDI), 4 domains: executive functions, selective attention, visual memory, and verbal memory were assessed. Statistical tests of multi-variable analysis of variance, Tukey test, and co-variance analysis method were applied in data analysis. Results: Non-psychotic major depressive patients with history of suicide attempt performed significantly worse than the other two groups on WCST (p

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