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Neurotensin receptor 1 immunoreactivity in the peripheral ganglia and carotid body

Author(s): A. Porzionato | V. Macchi | A. Amagliani | I. Castagliuolo | A. Parenti | R. De Caro

Journal: European Journal of Histochemistry
ISSN 1121-760X

Volume: 53;
Issue: 3;
Start page: e16;
Date: 2009;
Original page

In the present study we investigated, through immunohistochemistry, the presence and location of neurotensin receptor 1 (NTR1) in the peripheral ganglia and carotid body of 16 humans and 5 rats. In both humans and rats, NTR1 immunostained ganglion cells were found in superior cervical ganglia (57.4±11.6% and 72.4±11.4%, respectively, p0.05), supporting a modulatory role for NT in these ganglia. Positivity was also detected in 45.6±9.2% and 50.8±6.8% of human and rat type I glomic cells, respectively, whereas type II cells were negative. Our findings suggest that NT produced by type I cells acts in an autocrine or paracrine way on the same cell type, playing a modulatory role on chemoception.
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